基质降解蛋白酶系统成分在人类癌症中的基质细胞表达。

Enzyme & protein Pub Date : 1996-01-01 DOI:10.1159/000468623
R Hewitt, K Danø
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引用次数: 80

摘要

基质降解蛋白酶系统的组成部分在人类癌症中通常由肿瘤浸润性基质细胞表达。这些分子的细胞表达模式似乎对每种癌症都是独特的。在一些病例中,在同一组织的非恶性重塑过程中观察到相似的模式。这些发现提示基质细胞积极参与肿瘤侵袭过程。讨论了这种新范式对癌症生物学和癌症治疗的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Stromal cell expression of components of matrix-degrading protease systems in human cancer.

Components of matrix-degrading protease systems are in human cancer often expressed by tumour-infiltrating stromal cells. The cellular pattern of expression of these molecules appears to be unique for each type of cancer. In several cases there are similarities with patterns observed in nonmalignant remodelling processes in the same tissue. These findings indicate that the stromal cells actively participate in the process of cancer invasion. The implications of this new paradigm for cancer biology and cancer treatment are discussed.

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