尿激酶纤溶酶原激活剂作为乳腺癌侵袭性疾病的预测因子

Enzyme & protein Pub Date : 1996-01-01 DOI:10.1159/000468618
M J Duffy, C Duggan, T Maguire, K Mulcahy, P Elvin, E McDermott, J J Fennelly, N O'Higgins
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引用次数: 36

摘要

尿激酶纤溶酶原激活物(uPA)是一种参与细胞外蛋白水解和信号转导的多功能蛋白。uPA通常在与膜结合受体(称为uPAR)结合时介导其作用。在这项研究中,uPA及其受体在乳腺癌中的蛋白和mRNA水平均被测量。在这两个水平上,uPA浓度与uPAR浓度显著相关。uPA水平也与组织蛋白酶B和组织蛋白酶D显著相关,但与组织蛋白酶L、MMP-8或MMP-9水平无关。无论使用何种临界值(例如,中位数、五分位数或四分位数值),uPA都是乳腺癌的重要预后标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Urokinase plasminogen activator as a predictor of aggressive disease in breast cancer.

Urokinase plasminogen activator (uPA) is a multifunctional protein involved in both extracellular proteolysis and signal transduction. uPA usually mediates its actions while attached to a membrane-bound receptor, termed uPAR. In this study, uPA and its receptor were measured at both protein and mRNA levels in breast cancer. At both levels, concentrations of uPA were significantly correlated with those for uPAR. uPA levels also correlated significantly with cathepsin B and cathepsin D but not with cathepsin L, MMP-8 or MMP-9 levels. Irrespective of the cut-off point used (e.g., median, tertile or quartile values), uPA was a significant prognostic marker for breast cancer.

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