{"title":"雌性荷尔蒙对未成熟大鼠子宫和肝脏中多胺氧化酶活性和多胺浓度的影响","authors":"O Dimitrov, V Pavlov, I Jotova","doi":"10.1007/BF01923991","DOIUrl":null,"url":null,"abstract":"<p><p>17 beta-estradiol (E2) and progesterone (P) treatment of immature female rats (10 micrograms/100 g body weight) respectively resulted in 1.38-fold (p < 0.02) and 1.42-fold (p < 0.02) increase in the uterine polyamine oxidase activity, and 2.45-fold (p < 0.001) and 1.43-fold (p < 0.02) increase in the uterine diamine oxidase activity, as compared to the controls. E2 caused a 5-fold (p < 0.05) and a 1.36-fold (p < 0.05) increase in putrescine and spermidine concentration respectively in rat uterus. Increases of 1.7-fold (p < 0.02) and 1.6-fold (p < 0.05) in putrescine and spermine concentration were determined in the P-treated uterus, as compared to the controls. The spermidine/spermine ratio, which is regarded as an index of growth rate, was higher in the E2-treated uterus and lower in the P-treated uterus than in the control uterus. No statistically significant hormonal effects were estimated in the immature liver. The data reported suggest the possibility of an involvement of polyamine-oxidizing enzymes in the modulation of polyamine concentrations in rat uterus by the female sex hormones.</p>","PeriodicalId":12087,"journal":{"name":"Experientia","volume":"52 8","pages":"795-8"},"PeriodicalIF":0.0000,"publicationDate":"1996-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01923991","citationCount":"10","resultStr":"{\"title\":\"Effects of female sex hormones on polyamine-oxidizing enzyme activities and polyamine concentrations in immature rat uterus and liver.\",\"authors\":\"O Dimitrov, V Pavlov, I Jotova\",\"doi\":\"10.1007/BF01923991\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>17 beta-estradiol (E2) and progesterone (P) treatment of immature female rats (10 micrograms/100 g body weight) respectively resulted in 1.38-fold (p < 0.02) and 1.42-fold (p < 0.02) increase in the uterine polyamine oxidase activity, and 2.45-fold (p < 0.001) and 1.43-fold (p < 0.02) increase in the uterine diamine oxidase activity, as compared to the controls. E2 caused a 5-fold (p < 0.05) and a 1.36-fold (p < 0.05) increase in putrescine and spermidine concentration respectively in rat uterus. Increases of 1.7-fold (p < 0.02) and 1.6-fold (p < 0.05) in putrescine and spermine concentration were determined in the P-treated uterus, as compared to the controls. The spermidine/spermine ratio, which is regarded as an index of growth rate, was higher in the E2-treated uterus and lower in the P-treated uterus than in the control uterus. No statistically significant hormonal effects were estimated in the immature liver. The data reported suggest the possibility of an involvement of polyamine-oxidizing enzymes in the modulation of polyamine concentrations in rat uterus by the female sex hormones.</p>\",\"PeriodicalId\":12087,\"journal\":{\"name\":\"Experientia\",\"volume\":\"52 8\",\"pages\":\"795-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/BF01923991\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experientia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/BF01923991\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experientia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF01923991","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of female sex hormones on polyamine-oxidizing enzyme activities and polyamine concentrations in immature rat uterus and liver.
17 beta-estradiol (E2) and progesterone (P) treatment of immature female rats (10 micrograms/100 g body weight) respectively resulted in 1.38-fold (p < 0.02) and 1.42-fold (p < 0.02) increase in the uterine polyamine oxidase activity, and 2.45-fold (p < 0.001) and 1.43-fold (p < 0.02) increase in the uterine diamine oxidase activity, as compared to the controls. E2 caused a 5-fold (p < 0.05) and a 1.36-fold (p < 0.05) increase in putrescine and spermidine concentration respectively in rat uterus. Increases of 1.7-fold (p < 0.02) and 1.6-fold (p < 0.05) in putrescine and spermine concentration were determined in the P-treated uterus, as compared to the controls. The spermidine/spermine ratio, which is regarded as an index of growth rate, was higher in the E2-treated uterus and lower in the P-treated uterus than in the control uterus. No statistically significant hormonal effects were estimated in the immature liver. The data reported suggest the possibility of an involvement of polyamine-oxidizing enzymes in the modulation of polyamine concentrations in rat uterus by the female sex hormones.
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