实体肿瘤细胞因子受体的表达。

Therapeutic immunology Pub Date : 1995-04-01
J Ridings, P J Macardle, R W Byard, J Skinner, H Zola
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引用次数: 0

摘要

细胞因子受体的表达通过多种实体肿瘤组织进行检查,使用免疫荧光程序优化的敏感性。一些通常被认为只与免疫和造血系统相关的细胞因子被证明在实体肿瘤中表达。例如,乳腺癌经常表达IL-3受体的两条链、IL-2受体的β链、TNF -2受体、信号转导链CD130和c-kit。细胞因子受体的广泛表达表明,个体肿瘤的受体谱应该在应用涉及细胞因子管理的治疗之前确定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cytokine receptor expression by solid tumours.

The expression of cytokine receptors by a variety of solid tumour tissues was examined, using an immunofluorescence procedure optimized for sensitivity. Several cytokines generally considered as relevant only to the immune and haematopoietic systems were shown to be expressed by solid tumours. For example, breast carcinoma frequently expressed both chains of the IL-3 receptor, the beta chain of the IL-2 receptor, the TNF type two receptor, the signal-transducing chain CD130, and c-kit. The broad expression of cytokine receptors suggests that the receptor profile of individual tumours should be determined before the application of therapy that involves the administration of cytokines.

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