[急性环磷酰胺实验中中性粒细胞的功能]。

IF 0.2 4区医学 Q4 HEMATOLOGY

Gematologiya I Transfuziologiya Pub Date : 1996-01-01

I V Nesterova, N V Kolesnikova, G A Chudilova, E V Fomicheva

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引用次数: 0

摘要

采用小鼠F1(CBAx57BL)实验研究了环磷酰胺对循环中性粒细胞(NG)数量及其主要功能(受体、吞噬、杀微生物系统功能)的影响。在小剂量(0.5 mg/kg)和大剂量(150 mg/kg)环磷酰胺给药15和60 min后，测定羊红细胞中NG计数、携带受体的NG数量、互补EAC=POH、吞噬和消化活性以及nbt试验。结果表明，该药具有明显的剂量和时间相关效应，可诱导抑郁和刺激。所获得的数据可用于在肿瘤、淋巴增生性疾病、器官和组织移植的免疫抑制治疗中开发预防NG功能障碍引起的并发症的方法。

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本刊更多论文

[Neutrophil granulocyte function in an acute experiment with cyclophosphane].

Experiments of mice F1(CBAx57BL) were made to study cyclophosphamide effects on the number of circulating neutrophil granulocytes (NG) and on their main functions (receptor, phagocytic, function of microbicidal systems). NG count, the number of NG carrying receptors to sheep red cells, complementary EAC=POH, phagocytic and digestive activities and NBT-test were measured 15 and 60 min after administration of small (0.5 mg/kg) and large (150 mg/kg) doses of cyclophosphamide. The results suggest clear dose- and time-related effect of the drug which can induce both depression and stimulation. The data obtained can be utilized in developing approaches to prevention of complications caused by NG dysfunctions in immunosuppressive therapy of tumors, lymphoproliferative diseases, organ and tissue transplantation.

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来源期刊

Gematologiya I Transfuziologiya 医学-血液学

CiteScore

0.80

自引率

66.70%

发文量

审稿时长

>12 weeks

期刊介绍： The journal publishes original theoretical and clinical studies, lectures, reviews, and practical notes concerning various problems of hematology and clinical and industrial transfusion. The journal provides information on the etiology, pathogenesis, diagnosis and treatment of blood disorders as well as on related non-hematological conditions (internal diseases, poisoning, exposure to ionizing radiation etc.).