[外周血自体造血干细胞移植在高剂量化疗后血液肿瘤和实体肿瘤患者中的应用]。

IF 0.2 4区医学 Q4 HEMATOLOGY

Gematologiya I Transfuziologiya Pub Date : 1996-01-01

V V Ptushkin, G D Selidovkin, K L Chimishkian, V B Larionova, Iu V Chervonobab, D M Mkheidze, S M Portnoĭ, S A Tiulndin

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引用次数: 0

摘要

正常造血和化疗后外周血单核细胞或/和细胞素在血细胞分离器上分离并冷冻保存。本文对22例不同血液学及实体恶性肿瘤患者的细胞进行了检测。刺激后可迅速收集到造血前体含量高的单核细胞。在对预后不利的患者进行超高剂量化疗后，移植这种材料可以快速持久地恢复造血功能。细胞素(粒细胞和粒细胞-巨噬细胞生长因子)促进外周血造血细胞前体快速可靠的产生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[Use of autologous hematopoietic stem cells from peripheral blood for transplantation in patients with hematologic and solid neoplasms after high-dose chemotherapy].

Peripheral mononuclears under normal hemopoiesis and after chemotherapy or/and cytokin were isolated on blood cell separator and cryopreserved. The cells from 22 patients with different hematological and solid malignancies were examined. Mononuclears with high content of hemopoiesis precursors may be collected rapidly after stimulation. Fast and persistent recovery of hemopoiesis in transplantation of this material after superhigh-dose chemotherapy of prognostically unfavourable patients is demonstrated. Cytokin (granulocytic and granulocytic-macrophagal growth factors) promoted fast and reliable production of sufficient quantities of peripheral blood hemopoiesis cells precursors.

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来源期刊

Gematologiya I Transfuziologiya 医学-血液学

CiteScore

0.80

自引率

66.70%

发文量

审稿时长

>12 weeks

期刊介绍： The journal publishes original theoretical and clinical studies, lectures, reviews, and practical notes concerning various problems of hematology and clinical and industrial transfusion. The journal provides information on the etiology, pathogenesis, diagnosis and treatment of blood disorders as well as on related non-hematological conditions (internal diseases, poisoning, exposure to ionizing radiation etc.).