暂时性双侧颈动脉夹持对大鼠参考记忆的影响。

C Heim, K H Sontag
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引用次数: 8

摘要

大鼠在戊巴比妥麻醉下双侧夹持颈动脉(BCCA) 60分钟,并在孔板中进行测试,25个孔中有8个孔按顺序隐藏诱饵食物颗粒。在术后2-14天的习得期,所有大鼠都学会了将模式识别为参考,即参考记忆。在29-37、165-175和240-250天后的回忆测试中,BCCA动物的记忆力下降,而参考记忆错误显著增加。工作记忆错误的数量,即重新检查先前检查过的诱饵孔,与假手术对照组没有区别。与对照组相比,BCCA组动物从1号孔到8号孔依次进食的颗粒数量显著减少,而两组动物检查的孔数相同。因此,观察到的行为变化似乎不是由运动或动机缺陷引起的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reference memory is affected by transient bilateral clamping of the carotid arteries in rats (BCCA).

Rats were subjected to 60 min of bilateral clamping of the carotid arteries (BCCA) in pentobarbital anaesthesia and tested in a hole board with 8 of the 25 holes baited with food pellets hidden in a serial order. All rats learned to recognize the pattern as a reference during an acquisition period at 2-14 days post surgery, i.e. reference memory. During the recall tests 29-37, 165-175 and 240-250 days later BCCA animals showed a decrease in memory revealing a significant increase in reference memory errors. The number of working memory errors, i.e. reexamination of inspected previously baited holes, did not differ from those of sham operated controls. The number of pellets eaten in serial order from hole 1 to hole 8 was significantly decreased in BCCA animals compared with controls, while the number of holes inspected by the animals in the two groups were the same. Thus the observed behaviour changes appear not to be caused by motor or motivation deficiencies.

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