{"title":"K+通道激活介导人嗜酸性细胞产生氧自由基的可能机制","authors":"Mitsuyo Saito , Ichiro Hisatome , Shigenori Nakajima , Ryoichi Sato","doi":"10.1016/0922-4106(95)90147-7","DOIUrl":null,"url":null,"abstract":"<div><p>Quinidine hydrochloride, as potent K<sup>+</sup> channel blocker, reduced luminol-dependent chemiluminescence products evoked by the addition of the calcium ionophore A23187 to eosinophils from patients with hypereosinophilic syndrome (<em>n</em> = 3) in a concentration-dependent manner (10<sup>−5</sup> mM to 1.0 mM quinidine). A23187 is known to cause increasses in intracellular Ca<sup>2+</sup> concentrations in eosinophils. Our results indicate that the production of reactive oxygen species by human eosinophils may be affected by Ca<sup>2+</sup> -activated K<sup>+</sup> channels.</p></div>","PeriodicalId":100502,"journal":{"name":"European Journal of Pharmacology: Molecular Pharmacology","volume":"291 2","pages":"Pages 217-219"},"PeriodicalIF":0.0000,"publicationDate":"1995-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0922-4106(95)90147-7","citationCount":"12","resultStr":"{\"title\":\"Possible mechanism of oxygen radical production by human eosinophils mediated by K+ channel activation\",\"authors\":\"Mitsuyo Saito , Ichiro Hisatome , Shigenori Nakajima , Ryoichi Sato\",\"doi\":\"10.1016/0922-4106(95)90147-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Quinidine hydrochloride, as potent K<sup>+</sup> channel blocker, reduced luminol-dependent chemiluminescence products evoked by the addition of the calcium ionophore A23187 to eosinophils from patients with hypereosinophilic syndrome (<em>n</em> = 3) in a concentration-dependent manner (10<sup>−5</sup> mM to 1.0 mM quinidine). A23187 is known to cause increasses in intracellular Ca<sup>2+</sup> concentrations in eosinophils. Our results indicate that the production of reactive oxygen species by human eosinophils may be affected by Ca<sup>2+</sup> -activated K<sup>+</sup> channels.</p></div>\",\"PeriodicalId\":100502,\"journal\":{\"name\":\"European Journal of Pharmacology: Molecular Pharmacology\",\"volume\":\"291 2\",\"pages\":\"Pages 217-219\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0922-4106(95)90147-7\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Pharmacology: Molecular Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0922410695901477\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Pharmacology: Molecular Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0922410695901477","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Possible mechanism of oxygen radical production by human eosinophils mediated by K+ channel activation
Quinidine hydrochloride, as potent K+ channel blocker, reduced luminol-dependent chemiluminescence products evoked by the addition of the calcium ionophore A23187 to eosinophils from patients with hypereosinophilic syndrome (n = 3) in a concentration-dependent manner (10−5 mM to 1.0 mM quinidine). A23187 is known to cause increasses in intracellular Ca2+ concentrations in eosinophils. Our results indicate that the production of reactive oxygen species by human eosinophils may be affected by Ca2+ -activated K+ channels.
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