水合氯醛和氯仿碱的遗传毒性测定

Mutation Research Letters Pub Date : 1995-12-01 DOI:10.1016/0165-7992(95)90002-0

S. Giller , F. Le Curieux , L. Gauthier , F. Erb , D. Marzin

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引用次数: 21

摘要

对氯化副产物水合氯醛和氯吡啶进行了3次短期遗传毒性试验。Chloropicrine诱导鼠伤寒沙门氏菌TA100突变的效力是氯醛的100倍(波动试验)，与氯醛不同，在大肠杆菌菌株PQ37的SOS显色试验中呈阳性。另一方面，只有氯醛在体内暴露于两栖动物白肋蝾螈幼虫后，引起微核红细胞频率的显著增加。

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Genotoxicity assay of chloral hydrate and chloropicrine

The chlorination by-products chloral hydrate and chloropierine were assayed for genotoxicity in three short-term tests. Chloropicrine was 100-fold more potent than chloral in inducing mutations in strain TA100 of S. typhimurium (fluctuation test) and, at variance with chloral, was positive in the SOS chromotest using strain PQ37 of E. coli. On the other hand, only chloral caused a significant increase in the frequency of micronucleated erythrocytes following in vivo exposure of the amphibian Pleurodeles waltl newt larvae.

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Mutation Research Letters

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