Karen Harrigton-Brock, Carolyn L. Doerr, Martha M. Moore
{"title":"3-氯-4-(二氯甲基)-5-羟基-2(5H)-呋喃酮(MX)对L5178Y/TK+/−-3.7.2 c小鼠淋巴瘤细胞的致突变性和致裂性","authors":"Karen Harrigton-Brock, Carolyn L. Doerr, Martha M. Moore","doi":"10.1016/0165-7992(95)00052-6","DOIUrl":null,"url":null,"abstract":"<div><p>3-chloro-4(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was tested without exogenous activation in L51785/TK<sup>+/−</sup>-3.7.2C mouse lymphoma cells for mutation at the thymidine kinase locus and for clastogenicity. At a concentration of 0.75 μg/ml, the induced mutant frequency was 1027 per 10<sup>6</sup> survivors (survival = 11%). A concentration-related increase of large and small colony mutants was observed, but the majority of the MX induced mutants formed small colonies, consistent with the positive clastogenic response that was observed. MX primarily induced chromatid breaks and rearrangements (30 chromatid and 4 chromosome aberrations per 100 cells) at the 0.75 μg/ml dose. These studies indicate that MX induces a broad spectrum of genetic damage.</p></div>","PeriodicalId":100934,"journal":{"name":"Mutation Research Letters","volume":"348 3","pages":"Pages 105-110"},"PeriodicalIF":0.0000,"publicationDate":"1995-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0165-7992(95)00052-6","citationCount":"30","resultStr":"{\"title\":\"Mutagenicity and clastogenicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in L5178Y/TK+/−-3.7.2C mouse lymphoma cells\",\"authors\":\"Karen Harrigton-Brock, Carolyn L. Doerr, Martha M. Moore\",\"doi\":\"10.1016/0165-7992(95)00052-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>3-chloro-4(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was tested without exogenous activation in L51785/TK<sup>+/−</sup>-3.7.2C mouse lymphoma cells for mutation at the thymidine kinase locus and for clastogenicity. At a concentration of 0.75 μg/ml, the induced mutant frequency was 1027 per 10<sup>6</sup> survivors (survival = 11%). A concentration-related increase of large and small colony mutants was observed, but the majority of the MX induced mutants formed small colonies, consistent with the positive clastogenic response that was observed. MX primarily induced chromatid breaks and rearrangements (30 chromatid and 4 chromosome aberrations per 100 cells) at the 0.75 μg/ml dose. These studies indicate that MX induces a broad spectrum of genetic damage.</p></div>\",\"PeriodicalId\":100934,\"journal\":{\"name\":\"Mutation Research Letters\",\"volume\":\"348 3\",\"pages\":\"Pages 105-110\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0165-7992(95)00052-6\",\"citationCount\":\"30\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mutation Research Letters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0165799295000526\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research Letters","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0165799295000526","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mutagenicity and clastogenicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in L5178Y/TK+/−-3.7.2C mouse lymphoma cells
3-chloro-4(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was tested without exogenous activation in L51785/TK+/−-3.7.2C mouse lymphoma cells for mutation at the thymidine kinase locus and for clastogenicity. At a concentration of 0.75 μg/ml, the induced mutant frequency was 1027 per 106 survivors (survival = 11%). A concentration-related increase of large and small colony mutants was observed, but the majority of the MX induced mutants formed small colonies, consistent with the positive clastogenic response that was observed. MX primarily induced chromatid breaks and rearrangements (30 chromatid and 4 chromosome aberrations per 100 cells) at the 0.75 μg/ml dose. These studies indicate that MX induces a broad spectrum of genetic damage.
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