{"title":"帕金森病的发病机制和动物研究。","authors":"W H Oertel, A Kupsch","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>This article reviews the past year's literature on pathogenesis and animal studies of Parkinson's disease. Studies on aging, genetic aspects, environmental factors, melanin, altered iron metabolism, oxidative stress, defective mitochondrial respiration, excitatory amino acids, and trophic support are reviewed in relation to the vulnerability of dopaminergic nigral neurons and the pathogenesis of Parkinson's disease.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 3","pages":"323-32"},"PeriodicalIF":0.0000,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pathogenesis and animal studies of Parkinson's disease.\",\"authors\":\"W H Oertel, A Kupsch\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This article reviews the past year's literature on pathogenesis and animal studies of Parkinson's disease. Studies on aging, genetic aspects, environmental factors, melanin, altered iron metabolism, oxidative stress, defective mitochondrial respiration, excitatory amino acids, and trophic support are reviewed in relation to the vulnerability of dopaminergic nigral neurons and the pathogenesis of Parkinson's disease.</p>\",\"PeriodicalId\":77089,\"journal\":{\"name\":\"Current opinion in neurology and neurosurgery\",\"volume\":\"6 3\",\"pages\":\"323-32\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current opinion in neurology and neurosurgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in neurology and neurosurgery","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pathogenesis and animal studies of Parkinson's disease.
This article reviews the past year's literature on pathogenesis and animal studies of Parkinson's disease. Studies on aging, genetic aspects, environmental factors, melanin, altered iron metabolism, oxidative stress, defective mitochondrial respiration, excitatory amino acids, and trophic support are reviewed in relation to the vulnerability of dopaminergic nigral neurons and the pathogenesis of Parkinson's disease.
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