[大鼠造血基质克隆前体细胞(CFU-F)从辐射损伤中恢复的能力]。

Radiobiologiia Pub Date : 1993-03-01
A I Kolesnikova, A G Konopliannikov, S Sh Kal'sina, L A Lepekhina, A V Zaĭtsev, A A Waĭnson
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引用次数: 0

摘要

已经研究了存在于成年大鼠骨髓中的造血基质(CFU-F)细胞前体从潜在致死和亚致死辐射损伤中恢复的能力。就潜在的致命损害而言,最高的可修复性表现为最耐辐射的CFU-F种群,它们在培养物中形成松散的菌落(克隆);观察到的是剂量-反应曲线的斜率,而不是外推数、变化和CFU-F人群的异质性。结果证实了CFU-F群体存在异质性,这是在研究其放射敏感性时通过在培养物中形成致密和松散的成纤维细胞菌落而揭示的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The capacity of rat clonogenic precursor cells of the hemopoietic stroma (CFU-F) to recover from radiation damages].

The ability of cell precursors of the haemopoietic stroma (CFU-F), that are present in the bone marrow of adult rats, to recover from potentially lethal and sublethal radiation damages has been investigated. The highest reparability, with respect to potentially lethal damages, is displayed by the most radioresistant CFU-F population, that forms loose colonies (clones) in a culture; the slope of the dose-response curve, not the extrapolation number, changes, and heterogeneity of the CFU-F population is observed. The results obtained confirm the presence of heterogeneity in the population of CFU-F, that was revealed in studying their radiosensitivity by the formation of dense and loose fibroblast colonies in a culture.

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