包封大鼠胰岛移植治疗糖尿病小鼠的长期观察。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1993-01-01 DOI:10.3109/10731199309118299

C Shu, J He

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引用次数: 3

摘要

将包被免疫分离膜的大鼠胰岛腹腔移植至11只链脲佐菌素诱导的糖尿病小鼠。非包膜异种移植物组11例全部排斥，有效率91%。4只小鼠血糖完全缓解，正常血糖持续时间最长为360天。观察长期移植成功组胰岛的病理变化，发现胰岛萎缩。结果表明，免疫分离膜具有保护异种移植排斥反应的作用。

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The long-term observation of the transplantation of encapsulated rat islets to the diabetic mice.

Rat islets encapsulated in the immuno-isolated membrane were transplanted intraperitoneally into 11 streptozotocin induced diabetic mice. The effective rate was 91% while all rejected in the 11 nonencapsulated xenograft group. 4 mice showed complete remission and longest normoglycemic period in those mice was 360 days. The pathological changes of islets of the long-term successful xenograft group were studied and showed atrophy. It proved that the immuno-isolated membrane can protect rejection during xeno-transplantation.

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Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology

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