{"title":"抗利尿激素和催产素受体特异性激动剂和拮抗剂的设计、合成和一些用途。","authors":"M Manning, W H Sawyer","doi":"10.3109/10799899309073655","DOIUrl":null,"url":null,"abstract":"<p><p>Selective agonists and antagonists are powerful tools for studies on AVP and OT receptors and on the physiological and pathophysiological roles of AVP and OT. Here we show how some of these peptides and their radiolabelled derivatives were designed. We also present examples of the currently available cyclic and linear OT and AVP agonists and antagonists from our laboratories.</p>","PeriodicalId":16948,"journal":{"name":"Journal of receptor research","volume":"13 1-4","pages":"195-214"},"PeriodicalIF":0.0000,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10799899309073655","citationCount":"86","resultStr":"{\"title\":\"Design, synthesis and some uses of receptor-specific agonists and antagonists of vasopressin and oxytocin.\",\"authors\":\"M Manning, W H Sawyer\",\"doi\":\"10.3109/10799899309073655\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Selective agonists and antagonists are powerful tools for studies on AVP and OT receptors and on the physiological and pathophysiological roles of AVP and OT. Here we show how some of these peptides and their radiolabelled derivatives were designed. We also present examples of the currently available cyclic and linear OT and AVP agonists and antagonists from our laboratories.</p>\",\"PeriodicalId\":16948,\"journal\":{\"name\":\"Journal of receptor research\",\"volume\":\"13 1-4\",\"pages\":\"195-214\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/10799899309073655\",\"citationCount\":\"86\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of receptor research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3109/10799899309073655\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of receptor research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/10799899309073655","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Design, synthesis and some uses of receptor-specific agonists and antagonists of vasopressin and oxytocin.
Selective agonists and antagonists are powerful tools for studies on AVP and OT receptors and on the physiological and pathophysiological roles of AVP and OT. Here we show how some of these peptides and their radiolabelled derivatives were designed. We also present examples of the currently available cyclic and linear OT and AVP agonists and antagonists from our laboratories.
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