GM-CSF/IL-3融合蛋白促进亚致死辐照恒河猴中性粒细胞和血小板恢复。

Biotechnology therapeutics Pub Date : 1993-01-01

D E Williams, J T Dunn, L S Park, E A Frieden, F R Seiler, A M Farese, T J Macvittie

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摘要

人GM-CSF/IL-3融合蛋白(PIXY321)在亚致死照射后的灵长类动物反跳造血模型中检测了其作用。结果表明，中性粒细胞和血小板再生率提高，以及循环中性粒细胞的功能激活。

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A GM-CSF/IL-3 fusion protein promotes neutrophil and platelet recovery in sublethally irradiated rhesus monkeys.

The effects of a human GM-CSF/IL-3 fusion protein (PIXY321) were examined in a primate model of rebound hematopoiesis following sublethal irradiation. The results demonstrated an enhanced rate of both neutrophil and platelet regeneration, as well as functional activation of circulating neutrophils.

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Biotechnology therapeutics

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