重组人脂皮素1(膜联蛋白1)在体外具有抗凝血活性。

Journal of lipid mediators Pub Date : 1993-10-01
G Cirino, C Cicala
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引用次数: 0

摘要

脂质化蛋白1是钙和磷脂结合蛋白脂质化蛋白中的一员(Di Rosa et al. (1984) Prostglandins 28,441 -442),也被称为膜联蛋白(Crumpton (1990) Nature 345, 212)。在本研究中,我们发现人重组脂皮质素-1可以增加体外人血浆活化的部分凝血活素时间,但不能增加凝血酶原时间。这种作用是剂量和时间依赖的,并被多克隆抗脂皮质素-1抗体逆转。据我们所知,这是首次证明重组蛋白在人血浆中具有与天然蛋白相同的活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Human recombinant lipocortin 1 (annexin 1) has anticoagulant activity on human plasma in vitro.

Lipocortin 1 is a member of a group of calcium and phospholipid binding proteins named lipocortins (Di Rosa et al. (1984) Prostglandins 28, 441-442) and also known as annexins (Crumpton (1990) Nature 345, 212). In this study we have shown that human recombinant lipocortin-1 can increase the activated partial thromboplastin time but not the prothrombin time of human plasma in vitro. This effect is dose and time dependent and is reversed by polyclonal anti-lipocortin-1 antibodies. To our knowledge, this is the first demonstration that the human recombinant protein has the same activity as the native protein on human plasma.

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