聚醚脲/多肽嵌段共聚物的合成及其与血液的相互作用。

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1993-01-01 DOI:10.3109/10731199309117659

Y Ito, K Miyashita, T Kashiwagi, Y Imanishi

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引用次数: 4

摘要

合成了聚氨酯/多肽嵌段共聚物。红外光谱和差示扫描量热法表明，在嵌段共聚物中，两段共聚物都经历了相混，而在聚氨酯/多肽共混体系中，两段共聚物都经历了相分离。接触角测量表明，嵌段共聚物中聚氨酯组分倾向于出现在膜表面，而聚氨酯/多肽共混物中多肽组分出现在膜表面。在体外实验中，嵌段共聚物的非血栓形成性与均聚物或聚合物共混物相似，尽管嵌段共聚物膜上的血小板粘附和变形受到抑制。

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Synthesis and interactions with blood of polyetherurethaneurea/polypeptide block copolymers.

Polyurethane/polypeptide block copolymers were synthesized. Infrared spectroscopy and differential scanning calorimetry revealed that in the block copolymers both segments undergo phase-mixing, while in polyurethane/polypeptide blend both components undergo phase-separation. Contact angle measurement showed that in the block copolymers polyurethane segments tended to appear on the membrane surface, whereas in polyurethane/polypeptide blend polypeptide components appeared on the membrane surface. In vitro nonthrombogenicity of the block copolymers was similar to that of homopolymers or polymer blends, though adhesion and deformation of platelets were suppressed on the block copolymer membranes.

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Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology

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