{"title":"凝集素:人少突胶质细胞瘤的可靠分化标志物。","authors":"J Figols, J Cervós-Navarro, F F Cruz-Sánchez","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Ninety tumours classified as well-differentiated oligodendrogliomas (43 cases) and anaplastic oligodendrogliomas (47 cases) were studied with glial fibrillary acidic protein (GFAP) and bound with different lectins including: peanut agglutinin (PNA), concanavalin A (Con A), wheat germ agglutinin (WGA) and Ricinus communis agglutinin (RCA-1). PNA has shown high affinity to cellular membranes of well-differentiated oligodendrogliomas. The affinity decreases with the cellular differentiation to astrocytic lines and is lost in anaplastic oligodendrogliomas. Con A labelling is restricted to anaplastic oligodendroglioma cells and to reactive astrocytes showing a predominant somatic (cytoplasmatic) pattern of staining. Our findings showed that a combined search with GFAP and lectins may allow an accurate grading of oligodendrogliomas.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lectins: reliable differentiation markers in human oligodendrogliomas.\",\"authors\":\"J Figols, J Cervós-Navarro, F F Cruz-Sánchez\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ninety tumours classified as well-differentiated oligodendrogliomas (43 cases) and anaplastic oligodendrogliomas (47 cases) were studied with glial fibrillary acidic protein (GFAP) and bound with different lectins including: peanut agglutinin (PNA), concanavalin A (Con A), wheat germ agglutinin (WGA) and Ricinus communis agglutinin (RCA-1). PNA has shown high affinity to cellular membranes of well-differentiated oligodendrogliomas. The affinity decreases with the cellular differentiation to astrocytic lines and is lost in anaplastic oligodendrogliomas. Con A labelling is restricted to anaplastic oligodendroglioma cells and to reactive astrocytes showing a predominant somatic (cytoplasmatic) pattern of staining. Our findings showed that a combined search with GFAP and lectins may allow an accurate grading of oligodendrogliomas.</p>\",\"PeriodicalId\":79360,\"journal\":{\"name\":\"Noshuyo byori = Brain tumor pathology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Noshuyo byori = Brain tumor pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Noshuyo byori = Brain tumor pathology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Lectins: reliable differentiation markers in human oligodendrogliomas.
Ninety tumours classified as well-differentiated oligodendrogliomas (43 cases) and anaplastic oligodendrogliomas (47 cases) were studied with glial fibrillary acidic protein (GFAP) and bound with different lectins including: peanut agglutinin (PNA), concanavalin A (Con A), wheat germ agglutinin (WGA) and Ricinus communis agglutinin (RCA-1). PNA has shown high affinity to cellular membranes of well-differentiated oligodendrogliomas. The affinity decreases with the cellular differentiation to astrocytic lines and is lost in anaplastic oligodendrogliomas. Con A labelling is restricted to anaplastic oligodendroglioma cells and to reactive astrocytes showing a predominant somatic (cytoplasmatic) pattern of staining. Our findings showed that a combined search with GFAP and lectins may allow an accurate grading of oligodendrogliomas.
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