一些“困难的序列”变得简单。固相肽合成中链间结合的研究。

International journal of peptide and protein research Pub Date : 1994-05-01

C Hyde, T Johnson, D Owen, M Quibell, R C Sheppard

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引用次数: 0

摘要

采用连续流fmoc -聚酰胺技术固相合成一些“困难序列”的案例研究。采用了最近发现的溶剂改变和肽侧链和主链修饰方法来减少联想效应，并将结果与标准条件下的合成结果进行了比较。

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Some 'difficult sequences' made easy. A study of interchain association in solid-phase peptide synthesis.

Case studies of the solid-phase synthesis of some 'difficult sequences' using continuous-flow Fmoc-polyamide techniques are presented. Solvent change and peptide side chain and backbone modification procedures recently found to reduce association effects are applied, and the results compared to syntheses under standard conditions.

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International journal of peptide and protein research

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