近足月奶牛外周血、子宫、卵巢和胎儿血液中的孕激素。

T Janowski
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引用次数: 3

摘要

本研究的目的是确定牛胎盘是否能够在体内产生孕激素代谢物。采用HPLC-RIA法测定了7头近月龄奶牛外周血、子宫、胎儿和卵巢血中5 -孕酮-3 α -20 α -二醇、17 α、20 α -二羟孕酮和孕酮的浓度。母体子宫和脐带循环动静脉差异的测量证实了5 - β -妊娠-3 α,20 α -二醇和17 α,20 α -二羟孕酮的胎盘起源,但不是孕酮本身。5 -孕酮-3 α,20 α -二醇优先分泌到胎室。根据早期的体外研究,本实验证实了早产牛胎盘能够在体内利用和分泌孕激素代谢物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gestagens in peripheral, uterine, ovarian and fetal blood in cows near term.

The aim of this study was to determine if bovine placenta is capable of producing the gestagen metabolites in vivo. The concentrations of 5 beta-pregnane-3 alpha-20 alpha-diol, 17 alpha,20 alpha-dihydroxyprogesterone and progesterone were measured by HPLC-RIA in samples obtained after surgical preparation from peripheral, uterine, fetal and ovarian blood of seven cows near term. Measurement of arterio-venous differences in maternal uterine and umbilical circulation confirmed the placental origin of 5 beta-pregnance-3 alpha,20 alpha-diol and 17 alpha,20 alpha-dihydroxyprogesterone, but not progesterone itself. 5 beta-pregnane-3 alpha,20 alpha-diol was preferentially secreted into the fetal compartment. The present experiment, according to earlier in-vitro studies, confirms that the preterm bovine placenta is qualified for in-vivo utilization and secretion of gestagen metabolites.

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