两种含强力霉素的可吸收基材对龈下菌群的抑菌效果比较。

I L Taner, G Ozcan, T Doğanay, M Iscanolu, B Taplamacioğlu, S E Gültekin, K Baloş
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引用次数: 15

摘要

采用羟丙基甲基纤维素(HPMC)和含40%多西环素(DOXY)的甲基纤维素(MC)基材,研究了局部给药对龈下菌斑菌群的影响。在初步检查后,从志愿者中选择了11例患者,这些患者至少有4个口袋,深度超过5毫米,伴有单根牙。随机选择两个口袋,每周两次插入HPMC和MC条,持续6周。一个口袋不接受治疗,另一个口袋只进行清理和刨根。0、1、3、6和10w时的基线和随访测量包括探探深度、牙龈收缩、探探出血和沟沟液流量。同时取龈下细菌标本进行暗场显微镜检查。HPMC贴片的体外药物释放量大于MC贴片。用HPMC或MC贴片或机械清创治疗的口袋中,许多临床参数均有显著改善。在处理期间和处理后,活动生物的相对比例明显下降。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the antibacterial effects on subgingival microflora of two different resorbable base materials containing doxycycline.

A study was conducted to evaluate the effects of local drug delivery on subgingival plaque flora using hydroxypropylmethylcellulose (HPMC) and methylcellulose (MC) base material containing 40% doxycycline (DOXY). Eleven patients who had at least four pockets exceeding 5 mm in depth associated with a single rooted tooth were selected from volunteers after an initial examination. Two of the pockets were chosen at random for insertion of the HPMC and MC strips twice a week for 6 w. One pocket received no treatment, and the other was debrided and root-planed only. Baseline and follow-up measurements at 0, 1, 3, 6, and 10w included probing depth, gingival shrinkage, bleeding on probing and crevicular fluid flow. Subgingival bacterial samples were also taken for dark-field microscopy. In vitro drug release from the HPMC strips was greater than that from MC. Significant improvements in many clinical parameters occurred in the pockets treated with HPMC or MC strips, or mechanical debridement. There was a marked decrease in the relative proportions of motile organisms during and after treatment.

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