PS-15与磺胺甲恶唑联用后的活性。

Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) Pub Date : 1994-06-01

A E Yeo, K H Rieckmann

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引用次数: 0

摘要

PS-15是一种新的双胍叶酸拮抗剂，在体内代谢为WR99210, WR99210是一种体外对多重耐药恶性疟原虫菌株非常活跃的代谢物。当将PS-15与磺胺甲恶唑联合施用于健康的猕猴时，血清抗疟疾活性明显高于单独施用PS-15的猴子。应该进行进一步的研究，以确定PS-15/磺胺组合在治疗人类疟疾感染和防止出现耐药寄生虫方面的价值。

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The activity of PS-15 in combination with sulfamethoxazole.

PS-15 is a novel biguanide folate antagonist that is metabolized in vivo to WR99210, a metabolite that is extremely active in vitro against multi-drug resistant strains of Plasmodium falciparum. When PS-15 was administered in combination with sulfamethoxazole to healthy Saimiri sciureus monkeys, the serum antimalarial activity was considerably greater than that observed in monkeys that received PS-15 alone. Further studies should be carried out to determine the value of PS-15/sulfonamide combinations in the treatment of human malaria infections and in preventing the emergence of drug-resistant parasites.

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Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)

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