Adenosine and other mast cell preformed mediators.

Earlier studies of adenosine as a modulator of mast cell secretory functions have demonstrated that addition of exogenous adenosine to rat peritoneal mast cells has appeared to be a pro-inflammatory molecule in allergic reactions. More recent investigative studies with mouse bone-marrow mast cells have confirmed the role of adenosine as a potent augmenter of mast cell mediator release. Ongoing investigation is centered on characterization of an adenosine subtype in mast cells and biochemical mechanisms by which adenosine may effect bronchoconstrictor response in allergen-sensitive individuals.