{"title":"正常生理病理状态下的胰岛素样生长因子及其受体。","authors":"D LeRoith, C T Roberts","doi":"10.1515/jpem.1993.6.3-4.251","DOIUrl":null,"url":null,"abstract":"<p><p>The insulin-like growth factor system, which includes the IGFs, IGF-binding proteins and IGF receptors, plays an essential role in normal growth and development, as well as the cellular differentiation of a number of other important systems, including the reproductive and immune systems. IGF action has also been implicated in several pathological conditions, including tissue repair, malnutrition, diabetes and malignancy.</p>","PeriodicalId":79383,"journal":{"name":"The Journal of pediatric endocrinology","volume":"6 3-4","pages":"251-5"},"PeriodicalIF":0.0000,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/jpem.1993.6.3-4.251","citationCount":"21","resultStr":"{\"title\":\"Insulin-like growth factors and their receptors in normal physiology and pathological states.\",\"authors\":\"D LeRoith, C T Roberts\",\"doi\":\"10.1515/jpem.1993.6.3-4.251\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The insulin-like growth factor system, which includes the IGFs, IGF-binding proteins and IGF receptors, plays an essential role in normal growth and development, as well as the cellular differentiation of a number of other important systems, including the reproductive and immune systems. IGF action has also been implicated in several pathological conditions, including tissue repair, malnutrition, diabetes and malignancy.</p>\",\"PeriodicalId\":79383,\"journal\":{\"name\":\"The Journal of pediatric endocrinology\",\"volume\":\"6 3-4\",\"pages\":\"251-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1515/jpem.1993.6.3-4.251\",\"citationCount\":\"21\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of pediatric endocrinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1515/jpem.1993.6.3-4.251\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of pediatric endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/jpem.1993.6.3-4.251","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Insulin-like growth factors and their receptors in normal physiology and pathological states.
The insulin-like growth factor system, which includes the IGFs, IGF-binding proteins and IGF receptors, plays an essential role in normal growth and development, as well as the cellular differentiation of a number of other important systems, including the reproductive and immune systems. IGF action has also been implicated in several pathological conditions, including tissue repair, malnutrition, diabetes and malignancy.
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