{"title":"二酰基甘油:磷脂介导的信号转导的形成和功能","authors":"E.W. Haeffner","doi":"10.1016/0742-8413(93)90070-2","DOIUrl":null,"url":null,"abstract":"<div><p>1. Properties, distribution and multiplicity of phosphoinositidases (phospholipase C, PLC) are investigated.</p><p>2. Generation of diacylglycerol (DAG) by a variety of enzymes such as phosphoinositide and phosphatidylcholine specific PLC, by a combination of phospholipase D and phosphatidic hydrolase, and by triglyceride lipase is examined.</p><p>3. Ca<sup>2+</sup> and phospholipid-dependent protein kinase C act as the target of DAG messenger action.</p><p>4. There are differences in the formation of DAG in normal and transformal cell.</p></div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"105 3","pages":"Pages 337-345"},"PeriodicalIF":0.0000,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90070-2","citationCount":"6","resultStr":"{\"title\":\"Diacylglycerol: Formation and function in phospholipid-mediated signal transduction\",\"authors\":\"E.W. Haeffner\",\"doi\":\"10.1016/0742-8413(93)90070-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>1. Properties, distribution and multiplicity of phosphoinositidases (phospholipase C, PLC) are investigated.</p><p>2. Generation of diacylglycerol (DAG) by a variety of enzymes such as phosphoinositide and phosphatidylcholine specific PLC, by a combination of phospholipase D and phosphatidic hydrolase, and by triglyceride lipase is examined.</p><p>3. Ca<sup>2+</sup> and phospholipid-dependent protein kinase C act as the target of DAG messenger action.</p><p>4. There are differences in the formation of DAG in normal and transformal cell.</p></div>\",\"PeriodicalId\":72650,\"journal\":{\"name\":\"Comparative biochemistry and physiology. C: Comparative pharmacology\",\"volume\":\"105 3\",\"pages\":\"Pages 337-345\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0742-8413(93)90070-2\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative biochemistry and physiology. C: Comparative pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0742841393900702\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative biochemistry and physiology. C: Comparative pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0742841393900702","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Diacylglycerol: Formation and function in phospholipid-mediated signal transduction
1. Properties, distribution and multiplicity of phosphoinositidases (phospholipase C, PLC) are investigated.
2. Generation of diacylglycerol (DAG) by a variety of enzymes such as phosphoinositide and phosphatidylcholine specific PLC, by a combination of phospholipase D and phosphatidic hydrolase, and by triglyceride lipase is examined.
3. Ca2+ and phospholipid-dependent protein kinase C act as the target of DAG messenger action.
4. There are differences in the formation of DAG in normal and transformal cell.
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