D2O和乙醇在人体总水测量中的稀释度比较。

H G Endres, O Grüner
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引用次数: 24

摘要

用乙醇稀释法和D2O稳定同位素稀释法测量了20名健康志愿者(5名女性和15名男性)的总身体水分,主要是23至31岁的学生。两种指标物质均在限食限液12 h后,以0.8 g/kg体重的乙醇负荷和0.1 g/kg体重的D2O负荷口服。这是第一次直接比较乙醇和D2O稀释后的总水(TBW),结果显示乙醇的区室比D2O的小。TBW(乙醇)/TBW (D2O)的商数为97.7%,这与商数TBW (H2(18)O)/TBW (D2O)(= 97%)的数量级相同,该商数在文献中众所周知,可以相对准确地表示D2O稀释后TBW的高估值(基于酸质子的H/D交换)[36]。因此TBW(乙醇)的值与H2(18)O的值几乎相同,这就直接证明了乙醇只分布在体内的水中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of D2O and ethanol dilutions in total body water measurements in humans.

Total body water was measured by ethanol dilution and D2O stable isotope dilution in a group of 20 healthy volunteers (5 females and 15 males), predominantly 23- to 31-year-old students. Both indicator substances were given orally with an ethanol burden of 0.8 g/kg body weight and a D2O burden of 0.1 g/kg body weight after 12-h food and fluid restriction. This first direct comparison of total body water (TBW) from ethanol and D2O dilutions revealed the ethanol compartments to be smaller than those of D2O. The quotient of TBW (ethanol)/TBW (D2O) was 97.7%, which is the order of the quotient TBW (H2(18)O)/TBW (D2O) ( = 97%), well known from the literature and taken to represent relatively exactly the value of TBW overestimation (based on H/D exchange for acid protons) following D2O dilution [36]. Thus the value of TBW (ethanol) is almost identical to that of H2(18)O, which provides direct evidence that ethanol is distributed only in the body water.

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