心房利钠肽抑制精氨酸血管催产素对蟾蜍皮肤的利钠和水渗作用。

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pub Date : 1994-11-01

D M Berman, M O Soria, M Proto de Grifasi, A Coviello

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引用次数: 0

摘要

研究大鼠心房利钠肽(rANP)对激素刺激的渗透水通透性(Jw, hydrosmotic effect)和净离子传输(short-circuit current, SCC, natritic effect)在蟾蜍皮肤上的作用，以评估其传输机制。蟾蜍皮肤是具有类似哺乳动物远端肾元功能的组织。大鼠心房利钠肽rANP-99-126 (rANP)抑制受刺激的SCC和Jw在循环AMP产生前的一个部位达到亚最大浓度的精氨酸血管催产素(AVT)。血管紧张素转换酶抑制剂(ACEI) MK-422没有改变ANP对受刺激Jw的抑制作用。

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Atrial natriuretic peptide inhibited the natriferic and hydrosmotic effects of arginine vasotocin on toad skin.

The effect of rat atrial natriuretic peptide (rANP) on hormonal stimulated osmotic water permeability (Jw, hydrosmotic effect) and net ion transport (short-circuit current, SCC, natriferic effect) was studied on toad skin, a tissue with functional similarities to the mammalian distal nephron, in order to assess actions on transport mechanisms. Rat atrial natriuretic peptide, rANP-99-126 (rANP) inhibited stimulated SCC and Jw to submaximal concentrations of arginine vasotocin (AVT) at a site before cyclic AMP generation. The angiotensin-converting enzyme inhibitor (ACEI) MK-422 did not modify the inhibitory effect of ANP in the stimulated Jw.

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Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology

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