[An evaluation of the biological action of carbon disulfide in clinico-laboratory studies of exposed workers].

A representative group of 122 workers from shop "Predilen" with 7 to 15 years length of service in specialty is taken. The professional groups are formed on the basis of measured average-shift concentrations of carbon bisulphide in the air of the working place, which vary from 4 to 50 mg.m-3. In order to establish deviations in some of the basic links of the biochemical mechanism of the toxic compounds effect the following indices are traced: copper metabolism [copper concentration and activity of ceruloplasmin in the serum]; lipidic metabolism [content of cholesterol, cholesterol of high and low density, triglycerides, beta-lipoproteins and nonesterified lipidic acids in the serum]; intercellular substance of the connective tissue [glycoproteins, glycosaminoglycans and hexauronic acids in serum and urine]; immune status [immunoglobulins A, G and M in serum]; peripheral blood [leucocytes, DKK, morphology and lipid content in granulocytes]. Decrease of the lipids in granulocytes is registered, as well as reduction of the ceruloplasmin activity, increase of immunoglobulin M and glycosaminoglycans in urine. The already established deviations follow the "dose-effect" and "dose-response" dependence.