唾液对变形链球菌的免疫反应对自身免疫性疾病小鼠龋齿发生和发展的影响。

T Maeda, K Takamori, M Shima, Y Kurihara
{"title":"唾液对变形链球菌的免疫反应对自身免疫性疾病小鼠龋齿发生和发展的影响。","authors":"T Maeda,&nbsp;K Takamori,&nbsp;M Shima,&nbsp;Y Kurihara","doi":"10.2334/josnusd1959.37.41","DOIUrl":null,"url":null,"abstract":"<p><p>MRL/l strain mice, which possess a lymphoproliferative gene inducing swelling of systemic lymph nodes, develop a SLE (systemic lupus erythematosus)-like syndrome at around 8 w of age. MRL/n mice, which carry 99.6% of the genes of MRL/l mice, lack the gene for lymphoproliferation and exhibit only a slight degree of lymph node swelling late in life. This study investigated whether the salivary immune response caused by Streptococcus mutans(S. mutans) infection prevented dental caries in MRL/l and MRL/n mice after 8 w of age. A total of 10 MRL/l mice and 10 MRL/n mice were fed a commercial pellet diet without sucrose until 74 d of age, and then fed Diet 2000 containing 56% sucrose ad libitum from 75 to 130 d of age. On d 75, both strains of mice were inoculated with S. mutans JC-2 for 7 d. At 130 d of age, saliva samples were collected and caries scores were assessed. The results obtained suggested that the salivary immune response was one of the most important factors regulating caries occurrence.</p>","PeriodicalId":22638,"journal":{"name":"The Journal of Nihon University School of Dentistry","volume":"37 1","pages":"41-6"},"PeriodicalIF":0.0000,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2334/josnusd1959.37.41","citationCount":"1","resultStr":"{\"title\":\"Effects of salivary immune response to Streptococcus mutans on caries occurrence and caries development in mice with autoimmune disease.\",\"authors\":\"T Maeda,&nbsp;K Takamori,&nbsp;M Shima,&nbsp;Y Kurihara\",\"doi\":\"10.2334/josnusd1959.37.41\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>MRL/l strain mice, which possess a lymphoproliferative gene inducing swelling of systemic lymph nodes, develop a SLE (systemic lupus erythematosus)-like syndrome at around 8 w of age. MRL/n mice, which carry 99.6% of the genes of MRL/l mice, lack the gene for lymphoproliferation and exhibit only a slight degree of lymph node swelling late in life. This study investigated whether the salivary immune response caused by Streptococcus mutans(S. mutans) infection prevented dental caries in MRL/l and MRL/n mice after 8 w of age. A total of 10 MRL/l mice and 10 MRL/n mice were fed a commercial pellet diet without sucrose until 74 d of age, and then fed Diet 2000 containing 56% sucrose ad libitum from 75 to 130 d of age. On d 75, both strains of mice were inoculated with S. mutans JC-2 for 7 d. At 130 d of age, saliva samples were collected and caries scores were assessed. The results obtained suggested that the salivary immune response was one of the most important factors regulating caries occurrence.</p>\",\"PeriodicalId\":22638,\"journal\":{\"name\":\"The Journal of Nihon University School of Dentistry\",\"volume\":\"37 1\",\"pages\":\"41-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2334/josnusd1959.37.41\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Nihon University School of Dentistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2334/josnusd1959.37.41\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Nihon University School of Dentistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2334/josnusd1959.37.41","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

MRL/l品系小鼠具有诱导全身淋巴结肿胀的淋巴增生性基因,在8 w左右发生SLE(系统性红斑狼疮)样综合征。MRL/n小鼠携带99.6%的MRL/l小鼠基因,缺乏淋巴细胞增殖基因,在晚年仅表现出轻微的淋巴结肿胀。本研究探讨了变形链球菌(链球菌)引起的唾液免疫反应。MRL/l和MRL/n小鼠在8 w龄后可预防龋齿。选取10只MRL/l小鼠和10只MRL/n小鼠,在74日龄前饲喂不含蔗糖的商业颗粒饲料,在75 ~ 130日龄期间饲喂含56%蔗糖的饲料2000。在第75天,两株小鼠均接种变形链球菌JC-2 7 d。在130天龄时,收集唾液样本并评估龋齿评分。结果表明,唾液免疫反应是调节龋病发生的重要因素之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of salivary immune response to Streptococcus mutans on caries occurrence and caries development in mice with autoimmune disease.

MRL/l strain mice, which possess a lymphoproliferative gene inducing swelling of systemic lymph nodes, develop a SLE (systemic lupus erythematosus)-like syndrome at around 8 w of age. MRL/n mice, which carry 99.6% of the genes of MRL/l mice, lack the gene for lymphoproliferation and exhibit only a slight degree of lymph node swelling late in life. This study investigated whether the salivary immune response caused by Streptococcus mutans(S. mutans) infection prevented dental caries in MRL/l and MRL/n mice after 8 w of age. A total of 10 MRL/l mice and 10 MRL/n mice were fed a commercial pellet diet without sucrose until 74 d of age, and then fed Diet 2000 containing 56% sucrose ad libitum from 75 to 130 d of age. On d 75, both strains of mice were inoculated with S. mutans JC-2 for 7 d. At 130 d of age, saliva samples were collected and caries scores were assessed. The results obtained suggested that the salivary immune response was one of the most important factors regulating caries occurrence.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信