心房利钠因子拮抗血管紧张素诱导的血管加压素在大鼠皮质下器官的释放。

Acta neurologica Pub Date : 1994-12-01
L Steardo, M D Steardo, N Testa, A Attanasio, M Persichella, V Cuomo
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引用次数: 0

摘要

心房利钠因子(ANF)和血管紧张素II (Ang II)受体在皮质下器官的共存提示心房利钠因子可能在这一水平上影响Ang II的作用。为了验证这一假设,我们研究了ANF预注射到皮下器官(SFO)对Ang ii诱导的大鼠抗利尿激素释放的影响。ANF减弱循环中Ang II引起的抗利尿激素释放。本研究表明SFO是ANF-Ang II相互作用发生的主要位点之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Atrial natriuretic factor antagonises angiotensin II--induced vasopressin release in rat subfornical organ.

The coexistence of Atrial Natriuretic Factor (ANF) and Angiotensin II (Ang II) receptors in the subfornical organ suggested that ANF may influence the action of Ang II at this level. To test this hypothesis the effect of ANF pre injected into subfornical organ (SFO) on Ang II-induced vasopressin release was investigated in rats. ANF blunted vasopressin release elicited by circulating Ang II. This study indicates SFO as one of the main sites at which ANF-Ang II interactions occur.

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