James D. Tucker , Angela Auletta , Michael C. Cimino , Kerry L. Dearfield , David Jacobson-Kram , Raymond R. Tice , Anthony V. Carrano
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Sister-chromatid exchange: second report of the Gene-Tox program
This paper reviews the ability of a number of chemicals to induce sister-chromatid exchanges (SCEs). The SCE data for animal cells in vivo and in vitro, and human cells in vitro are presented in 6 tables according to their relative effectiveness. A seventh table summarizes what is known about the effects of specific chemicals on SCEs for humans exposed in vivo. The data support the concept that SCEs provide a useful indication of exposure, although the mechanism and biological significance of SCE formation still remain to be elucidated.
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