二甲基亚硝胺诱导大鼠肾上皮肿瘤基底膜物质过量生成。

C Brummer, A Nerlich, H M Rabes
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引用次数: 1

摘要

在二甲基亚硝胺在大鼠肾脏诱导的一系列瘤前病变和肿瘤实验中,54个肿瘤中有4个表现出特殊的形态特征,使它们能够单独分组。这些病变的主要特征是肿瘤细胞包埋在丰富的pas阳性基质中。肿瘤基质中存在不同数量的层粘连蛋白、硫酸肝素蛋白多糖、IV型和V型胶原,这为其由基底膜物质组成提供了间接证据。由于肿瘤细胞与基质密切接触,没有成纤维细胞存在,因此假定基质是肿瘤细胞的产物。到目前为止,还没有在实验动物中发现类似的肾脏肿瘤,也没有发现与人类类似的肿瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Excessive basement membrane material production by epithelial tumors induced by dimethylnitrosamine in rat kidneys.

In an experimental series of preneoplastic lesions and neoplasms induced in the rat kidney by dimethylnitrosamine, four of the 54 tumors showed particular morphological features that allowed them to be grouped separately. The leading characteristic of these lesions was an abundant PAS-positive matrix in which the tumor cells were embedded. The demonstration of variable amounts of laminin, heparan sulfate proteoglycan, collagen types IV and V in the tumor matrix provided circumstantial evidence that it consisted of basement membrane material. Since the tumor cells were in intimate contact with the matrix and no fibroblasts were present, it was assumed that the matrix was a product of the tumor cells. Until now, no similar renal tumors have been described in laboratory animals and no human equivalent is known.

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