Barbara Malinowska , Manfred Göthert , Grzegorz Godlewski , Beata Wróbel , Heinz Bönisch , Włodzimierz Buczko
{"title":"乙醇对5-羟色胺诱导的外周5-HT3受体参与Bezold-Jarisch反射的抑制作用","authors":"Barbara Malinowska , Manfred Göthert , Grzegorz Godlewski , Beata Wróbel , Heinz Bönisch , Włodzimierz Buczko","doi":"10.1016/0926-6917(95)90020-9","DOIUrl":null,"url":null,"abstract":"<div><p>The influence of ethanol (0.5, 1.0 and 2.0 g/kg i.p.) on the Bezold-Jarisch reflex in urethane-anesthetized rats was studied. 5-Hydroxytryptamine (serotonin; 5-HT; 1, 3, 10 and 30 μg/kg i.v.) and capsaicin (1, 3 and 10 μg/kg i.v.) reflexly decreased heart rate in a dose-dependent manner. The 5-HT<sub>3</sub> receptor antagonist ondansetron 10 μg/kg i.v. abolished the 5-HT- but not the capsaicin-stimulated bradycardia, indicating that 5-HT and capsaicin acted via different trigger mechanisms (5-HT<sub>3</sub> receptor-dependent and -independent, respectively). Ethanol at 1.0 and 2.0 g/kg i.p. inhibited in a dose-dependent manner (by 20–45%) the 5-HT- but not the capsaicin-stimulated decrease in heart rate. Our results demonstrate that the inhibitory effect of ethanol on the 5-HT<sub>3</sub> receptor-mediated Bezold-Jarisch reflex may be related to the direct effect of ethanol on 5-HT<sub>3</sub> receptors on sensory vagal nerves in the heart.</p></div>","PeriodicalId":100501,"journal":{"name":"European Journal of Pharmacology: Environmental Toxicology and Pharmacology","volume":"293 1","pages":"Pages 71-76"},"PeriodicalIF":0.0000,"publicationDate":"1995-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6917(95)90020-9","citationCount":"9","resultStr":"{\"title\":\"Inhibitory effect of ethanol on the 5-hydroxytryptamine-induced Bezold-Jarisch reflex — involvement of peripheral 5-HT3 receptors\",\"authors\":\"Barbara Malinowska , Manfred Göthert , Grzegorz Godlewski , Beata Wróbel , Heinz Bönisch , Włodzimierz Buczko\",\"doi\":\"10.1016/0926-6917(95)90020-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The influence of ethanol (0.5, 1.0 and 2.0 g/kg i.p.) on the Bezold-Jarisch reflex in urethane-anesthetized rats was studied. 5-Hydroxytryptamine (serotonin; 5-HT; 1, 3, 10 and 30 μg/kg i.v.) and capsaicin (1, 3 and 10 μg/kg i.v.) reflexly decreased heart rate in a dose-dependent manner. The 5-HT<sub>3</sub> receptor antagonist ondansetron 10 μg/kg i.v. abolished the 5-HT- but not the capsaicin-stimulated bradycardia, indicating that 5-HT and capsaicin acted via different trigger mechanisms (5-HT<sub>3</sub> receptor-dependent and -independent, respectively). Ethanol at 1.0 and 2.0 g/kg i.p. inhibited in a dose-dependent manner (by 20–45%) the 5-HT- but not the capsaicin-stimulated decrease in heart rate. Our results demonstrate that the inhibitory effect of ethanol on the 5-HT<sub>3</sub> receptor-mediated Bezold-Jarisch reflex may be related to the direct effect of ethanol on 5-HT<sub>3</sub> receptors on sensory vagal nerves in the heart.</p></div>\",\"PeriodicalId\":100501,\"journal\":{\"name\":\"European Journal of Pharmacology: Environmental Toxicology and Pharmacology\",\"volume\":\"293 1\",\"pages\":\"Pages 71-76\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-05-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0926-6917(95)90020-9\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Pharmacology: Environmental Toxicology and Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0926691795900209\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Pharmacology: Environmental Toxicology and Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0926691795900209","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Inhibitory effect of ethanol on the 5-hydroxytryptamine-induced Bezold-Jarisch reflex — involvement of peripheral 5-HT3 receptors
The influence of ethanol (0.5, 1.0 and 2.0 g/kg i.p.) on the Bezold-Jarisch reflex in urethane-anesthetized rats was studied. 5-Hydroxytryptamine (serotonin; 5-HT; 1, 3, 10 and 30 μg/kg i.v.) and capsaicin (1, 3 and 10 μg/kg i.v.) reflexly decreased heart rate in a dose-dependent manner. The 5-HT3 receptor antagonist ondansetron 10 μg/kg i.v. abolished the 5-HT- but not the capsaicin-stimulated bradycardia, indicating that 5-HT and capsaicin acted via different trigger mechanisms (5-HT3 receptor-dependent and -independent, respectively). Ethanol at 1.0 and 2.0 g/kg i.p. inhibited in a dose-dependent manner (by 20–45%) the 5-HT- but not the capsaicin-stimulated decrease in heart rate. Our results demonstrate that the inhibitory effect of ethanol on the 5-HT3 receptor-mediated Bezold-Jarisch reflex may be related to the direct effect of ethanol on 5-HT3 receptors on sensory vagal nerves in the heart.
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