中性粒细胞衍生的no合成酶(NOS)抑制剂。

A Dembinska-Kiec, M Burchert, J Hartwich, R Gryglewski, B A Peskar
{"title":"中性粒细胞衍生的no合成酶(NOS)抑制剂。","authors":"A Dembinska-Kiec,&nbsp;M Burchert,&nbsp;J Hartwich,&nbsp;R Gryglewski,&nbsp;B A Peskar","doi":"10.1007/978-3-0348-7346-8_23","DOIUrl":null,"url":null,"abstract":"<p><p>In the present work we have demonstrated that the low NOS activity of circulating blood neutrophils is related to an endogenous inhibitory factor. This factor inhibits constitutive NOS (cNOS) of cerebellum and inducible NOS (iNOS) of macrophages in a concentration-dependent manner. Boiling only partially diminished its activity. The inhibition of cNOS was specific, since to some degree NADPH (0.5-4 mM) and more effectively L-arginine (0.1-1 mM), but not D-arginine, reversed the inhibition.</p>","PeriodicalId":7491,"journal":{"name":"Agents and actions. Supplements","volume":"45 ","pages":"163-8"},"PeriodicalIF":0.0000,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"A neutrophil-derived NO-synthase (NOS) inhibitor.\",\"authors\":\"A Dembinska-Kiec,&nbsp;M Burchert,&nbsp;J Hartwich,&nbsp;R Gryglewski,&nbsp;B A Peskar\",\"doi\":\"10.1007/978-3-0348-7346-8_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In the present work we have demonstrated that the low NOS activity of circulating blood neutrophils is related to an endogenous inhibitory factor. This factor inhibits constitutive NOS (cNOS) of cerebellum and inducible NOS (iNOS) of macrophages in a concentration-dependent manner. Boiling only partially diminished its activity. The inhibition of cNOS was specific, since to some degree NADPH (0.5-4 mM) and more effectively L-arginine (0.1-1 mM), but not D-arginine, reversed the inhibition.</p>\",\"PeriodicalId\":7491,\"journal\":{\"name\":\"Agents and actions. Supplements\",\"volume\":\"45 \",\"pages\":\"163-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Agents and actions. Supplements\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/978-3-0348-7346-8_23\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Agents and actions. Supplements","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-0348-7346-8_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4

摘要

在目前的工作中,我们已经证明了循环血液中性粒细胞的低NOS活性与内源性抑制因子有关。该因子以浓度依赖性的方式抑制小脑组成性NOS (cNOS)和诱导巨噬细胞NOS (iNOS)。煮沸只是部分地降低了它的活性。对cNOS的抑制是特异性的,因为NADPH (0.5-4 mM)和l -精氨酸(0.1-1 mM)在一定程度上逆转了这种抑制,而d -精氨酸则没有。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A neutrophil-derived NO-synthase (NOS) inhibitor.

In the present work we have demonstrated that the low NOS activity of circulating blood neutrophils is related to an endogenous inhibitory factor. This factor inhibits constitutive NOS (cNOS) of cerebellum and inducible NOS (iNOS) of macrophages in a concentration-dependent manner. Boiling only partially diminished its activity. The inhibition of cNOS was specific, since to some degree NADPH (0.5-4 mM) and more effectively L-arginine (0.1-1 mM), but not D-arginine, reversed the inhibition.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信