P物质受体在帕金森病和阿尔茨海默病中受到不同的影响。

L Rioux, J N Joyce
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引用次数: 18

摘要

我们使用[125I] Bolton-Hunter标记物质P,通过受体放射自显影法定量测定了阿尔茨海默病(AD)和帕金森病(PD)患者纹状体和白质(内部(GPi)或外部(GPe)段)中NK1受体的数量。与非神经系统对照相比,PD患者纹状体中NK1位点的数量显著增加。GPi和GPe无显著差异。我们观察到AD病例中纹状体和苍白质中NK1位点的数量与对照组没有显著差异。然而,AD患者纹状体中NK1位点的数量明显低于PD患者。这些结果表明,PD患者基底神经节中NK1受体的表达受到影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Substance P receptors are differentially affected in Parkinson's and Alzheimer's disease.

We have quantified by receptor autoradiography the number of NK1 receptors, using [125I] Bolton-Hunter labeled substance P, in striatum and pallidum (internal (GPi) or external (GPe) segment) of patients suffering from Alzheimer's (AD) and Parkinson's disease (PD). When compared to non-neurologic controls, a significant increase in the number of NK1 sites has been observed in the striatum of PD patients. No significant differences were observed for the GPi and GPe. We observed no significant differences from controls in the number of NK1 sites in the striatum and pallidum of AD cases. However, the number of NK1 sites in the striatum of AD patients was significantly lower than that of PD patients. These results show that the expression of NK1 receptors in the basal ganglia is affected in PD.

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