帕金森氏症患者静脉输注P物质缺乏促肾上腺皮质激素/皮质醇和生长激素反应

R Volpi, P Caffarra, A Scaglioni, A Saginario, D Maestri, S Vourna, P P Vescovi, P Chiodera, V Coiro
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引用次数: 6

摘要

为了检测静脉注射P物质(SP)对帕金森病患者ACTH/皮质醇和GH分泌的刺激作用可能发生的变化,10名男性帕金森患者和10名年龄匹配的正常人静脉注射SP(1.0或1.5 pmol/kg-1/min-1 SP)或生理盐水60分钟。分别在SP或生理盐水输注期间和输注后20分钟内测定促肾上腺皮质激素、皮质醇和生长激素的循环水平。在SP输注过程中,未观察到任何不良副作用或血压变化。在基础条件下和生理盐水输注期间,正常和帕金森患者血浆ACTH和皮质醇水平相似。在SP输注期间,正常对照组的ACTH/皮质醇浓度与基线和生理盐水试验相比显著升高,且呈剂量依赖性。相比之下,在两种SP注入量下,帕金森患者的ACTH/皮质醇水平与生理盐水试验中观察到的相似。所有受试者的GH基础浓度相似。注射高剂量SP后,正常对照的生长激素水平明显升高,而注射低剂量SP或生理盐水对生长激素水平没有影响。在测试SP量和生理盐水输注期间,生长激素水平在帕金森患者中保持不变。与先前文献中显示帕金森大脑中SP异常的观察结果一致,这些数据未能显示血浆SP对帕金森病ACTH/皮质醇和GH分泌系统的显著影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lack of ACTH/cortisol and GH responses to intravenously-infused substance P in Parkinson's disease.

In order to test possible changes in the stimulating effect of intravenously-infused substance P (SP) on ACTH/cortisol and GH secretion in Parkinson's disease, 10 male parkinsonian patients and 10 age-matched normal controls were infused intravenously for 60 min with SP (1.0 or 1.5 pmol/kg-1/min-1 SP) or normal saline. The circulating levels of ACTH, cortisol and GH were measured during and for 20 min after SP or saline infusion. No untoward side effects or changes in blood pressure were observed during SP infusion in any subjects. In basal conditions and during saline infusion, plasma ACTH and cortisol levels were similar in normal and parkinsonian patients. During SP infusions, ACTH/cortisol concentrations in normal controls rose significantly vs baseline and saline test in a dose-dependent fashion. In contrast, at both SP infused amounts, parkinsonian patients showed ACTH/cortisol levels similar to those observed in the saline test. All subjects showed similar basal concentrations of GH. GH levels rose significantly in the normal controls when the higher dose of SP was infused, but they were not modified by the infusion of the lower dose of SP or saline. At both tested amounts of SP and during saline infusion, GH levels remained unchanged in the parkinsonian subjects. In agreement with previous observations in the literature showing SP abnormalities in the parkinsonian brain, these data fail to show significant effects of plasma SP on the ACTH/cortisol and GH secretory systems in Parkinson's disease.

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