Spontaneous activity and food requirements for maintenance and for growth in the genetically obese Zucker rat.

This study was undertaken in order to elucidate whether, as compared with those of their lean controls, the low maintenance requirements of genetically obese Zucker rats may be explained by a lower spontaneous activity. In 6 obese and 6 lean rats, daily body weight, food intake and spontaneous activity were recorded during 6 weeks, using a seismographic recorder. The obese rats weighed more (average + 46%) and ate more (average + 42%) than the lean rats, while there was no difference between their daily activity levels. The relationship between food intake (FI) and weight gain (delta W), both expressed per 100 g body weight, was: FI (kcal/day) = 3.3 delta W (g/day) + 20.4 for lean rats and 4.9 delta W (g/day) + 17.4 for obese rats. Thus, the food requirements for maintenance obtained for delta W = O was less than for obese than for lean rats, while for a given gain in body weight, it was higher for obese rats. This did not seem to be because of a lower daily activity level in the obese than in the lean rats.