{"title":"n -亚硝基somethylurea对Fisher淋巴结病L-5178耐药亚株的影响","authors":"E A Minenkova, M M Fomina, L S Evseenko","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>A cytogenetic analysis of variants of Fisher mouse lymphadenosis L-5178 resistant to the antitumoral antibiotics bruneomycin and rubomycin C showed that the cytogenetic characteristics of the changes in the tumor cell population correlate with the chemotherapeutic indices of the development of drug resistance. Cytogenetic and kinetic analyses showed that variants of Fisher lymphadenosis L-5178 resistant to bruneomycin and rubomycin C retain sensitivity to N-nitrosomethylurea (NMU). The activity of NMU in an experiment on resistant substrains of lymphadenosis can serve as a basis for the clinical use of NMU in the treatment of lymphomas resistant to antibiotics.</p>","PeriodicalId":9166,"journal":{"name":"Biology bulletin of the Academy of Sciences of the USSR","volume":"7 1","pages":"40-6"},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of N-nitrosomethylurea on substrains of Fisher lymphadenosis L-5178 resistant to antitumoral antibiotics.\",\"authors\":\"E A Minenkova, M M Fomina, L S Evseenko\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A cytogenetic analysis of variants of Fisher mouse lymphadenosis L-5178 resistant to the antitumoral antibiotics bruneomycin and rubomycin C showed that the cytogenetic characteristics of the changes in the tumor cell population correlate with the chemotherapeutic indices of the development of drug resistance. Cytogenetic and kinetic analyses showed that variants of Fisher lymphadenosis L-5178 resistant to bruneomycin and rubomycin C retain sensitivity to N-nitrosomethylurea (NMU). The activity of NMU in an experiment on resistant substrains of lymphadenosis can serve as a basis for the clinical use of NMU in the treatment of lymphomas resistant to antibiotics.</p>\",\"PeriodicalId\":9166,\"journal\":{\"name\":\"Biology bulletin of the Academy of Sciences of the USSR\",\"volume\":\"7 1\",\"pages\":\"40-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1980-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biology bulletin of the Academy of Sciences of the USSR\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biology bulletin of the Academy of Sciences of the USSR","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of N-nitrosomethylurea on substrains of Fisher lymphadenosis L-5178 resistant to antitumoral antibiotics.
A cytogenetic analysis of variants of Fisher mouse lymphadenosis L-5178 resistant to the antitumoral antibiotics bruneomycin and rubomycin C showed that the cytogenetic characteristics of the changes in the tumor cell population correlate with the chemotherapeutic indices of the development of drug resistance. Cytogenetic and kinetic analyses showed that variants of Fisher lymphadenosis L-5178 resistant to bruneomycin and rubomycin C retain sensitivity to N-nitrosomethylurea (NMU). The activity of NMU in an experiment on resistant substrains of lymphadenosis can serve as a basis for the clinical use of NMU in the treatment of lymphomas resistant to antibiotics.
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