磷壁酸在金黄色葡萄球菌与鼻上皮细胞结合中的作用。

IF 5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 1980-04-01 DOI:10.1093/infdis/141.4.463

R Aly, H R Shinefield, C Litz, H I Maibach

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引用次数: 127

摘要

研究了磷壁酸在金黄色葡萄球菌黏附鼻上皮细胞中的作用。用磷壁酸处理的上皮细胞显示金黄色葡萄球菌的结合减少。与对照组相比，经磷壁酸处理的上皮细胞粘附性降低71% (P < 0.001)。脂磷胆酸(从链球菌中获得)处理的上皮细胞也减少了金黄色葡萄球菌的粘附。这些数据提供了证据，证明磷壁酸介导了金黄色葡萄球菌对鼻粘膜细胞的粘附。

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Role of teichoic acid in the binding of Staphylococcus aureus to nasal epithelial cells.

The role of teichoic acid in the adherence of Staphylococcus aureus to nasal epithelial cells was investigated. Epithelial cells treated with teichoic acid demonstrated decreased binding of S. aureus. A 71% reduction of adherence was noted with teichoic acid-treated epithelial cells as compared with controls (P less than 0.001). Reduction in adherence of S. aureus was also noted with lipoteichoic acid (obtained from streptococci)-treated epithelial cells. The data provide evidence that teichoic acid mediates the adherence of S. aureus to nasal mucosal cells.

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.