[Effect of long-term plasmapheresis on blood composition. I. Changes in the concentration of total proteins, electrophoretic fractions and immunoglobulins].

Effects of long term plasmapheresis on blood constituents was examined in the plasma donors from whom 220-660 ml of plasma was withdrawn weakly. The donors were submitted 3-300 times to double plasmapheresis procedures. Small decreases in concentrations of total proteins, albumins, gamma-globulins, immunoglobulins IgA and IgM were observed as well as the increases in the concentrations of alpha-1-globulins (p less than 0,05), alpha-2-globulins (p less than 0,05), beta-globulins (p less than 0,05) and immunoglobulins IgG (p less than 0,05). The statistically significant changes were observed earlier in the course of plasmapheresis in donors submitted to more intensive regime.