大鼠妊娠期卵巢静脉流出量、孕酮和17 -雌二醇分泌及外周血水平的变化。

B Varga, E S Patay, E Horváth, G Folly
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引用次数: 0

摘要

妊娠第3天取大鼠右卵巢静脉血,测定卵巢静脉流出量和红细胞压积。采用RIA法测定卵巢静脉血和外周血中的孕酮和17 -雌二醇,计算孕酮和17 -雌二醇的分泌率(ng/min)和分泌率(pg/min)。卵巢静脉血流量在妊娠第9天和第12天升高,此时黄体酮分泌达到最高值。第15天血流量开始减少,第18天黄体酮分泌率下降。第21天,黄体酮分泌率恢复到第1天水平,但此时卵巢静脉血和外周血黄体酮浓度仍显著升高。17 -雌二醇分泌率从第12天开始呈逐渐升高的趋势,在第21天达到最高值。卵巢和外周静脉血17 -雌二醇水平从第15天开始平行升高。妊娠中期卵巢高水平的血流量和孕酮分泌被认为是源于胎盘的促黄体物质刺激的结果。由于妊娠期间卵巢静脉血流量发生变化,卵巢静脉血激素浓度并不是激素产生的可靠指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ovarian venous outflow, progesterone and 17 beta-oestradiol secretion and peripheral blood level during pregnancy in the rat.

Blood was collected from the right ovarian vein on every third day of pregnancy in rats and the ovarian venous outflow and haematocrit were measured. Progesterone and 17 beta-oestradiol were determined by RIA from the ovarian venous and peripheral blood and the secretion rate of progesterone (ng/min) and 17 beta-oestradiol (pg/min) was calculated. An elevated level of ovarian venous blood flow was found on day 9 and 12 of pregnancy when the progesterone secretion reached the highest values. Blood flow began to decrease on day 15, the progesterone secretion rate on day 18. On day 21, progesterone secretion rate returned to the day-1 level, however, at this time the progesterone concentration of ovarian venous blood and peripheral blood remained significantly elevated. Secretion rate of 17 beta-oestradiol showed a gradually tendency to increase from day 12 reaching the highest value on day 21. Ovarian and peripheral venous blood level of 17 beta-oestradiol increased parallelly from day 15. The high level of ovarian blood flow and progesterone secretion in mid-pregnancy is suggested to be the result of the stimulation of luteotropic material originating from the placenta. Since the ovarian venous blood flow changes during pregnancy, the hormone concentration of ovarian venous blood is not a reliable indicator of hormone production.

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