大鼠纹状体微量胺与多巴胺的相互作用

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90050-3

Glen B. Baker, Deborah L. Yasensky

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引用次数: 15

摘要

1.1. 研究了三种“微量”胺，即2-苯乙胺(PEA)、对酪胺(p-TA)和色胺(T)促进大鼠纹状体棱镜放射标记多巴胺(DA)释放的能力。在1.0 μM和10 μM浓度下，与对照组相比，三种胺均显著增加DA释放量。这种效应的强度顺序为p-TA >豌豆在T2.2。在T上添加α-甲基使其释放da的能力显著提高。将诺米芬(一种阻断DA载体转运的药物)引入到超融合培养基中，可显著减少微量胺从棱镜中释放的DA量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Interactions of trace amines with dopamine in rat striatum

1.
1. The ability of three ‘trace’ amines, namely 2-phenylethylamine (PEA), $p$ -tyramine ( $p$ -TA) and tryptamine (T) to facilitate the release of radiolabelled dopamine (DA) from prisms of rat striatum was investigated. At concentrations of 1.0 μM and 10 μM, all three amines caused a significant increase in DA release when compared to controls. The order of strength for this effect was $p$ -TA > PEA > T
2.
2. The addition of an α-methyl group on T caused a significant increase in its ability to release DA.
3.
3. The introduction of nomifensine, a drug which blocks carrier-mediated transport of DA, into the superfusion medium dramatically reduced the amount of DA released from the prisms by the trace amines.

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Progress in neuro-psychopharmacology

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