{"title":"用气相色谱和电子捕获检测筛选尿液中精神病学感兴趣的胺","authors":"R.T. Coutts, G.B. Baker, D.F. LeGatt, G.J. McIntosh, G. Hopkinson, W.G. Dewhurst","doi":"10.1016/0364-7722(81)90047-3","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. An electron-capture gas chromatographic procedure for the simultaneous quantitation of urinary levels of amines of psychiatric interest has been developed.</p></span></li><li><span>2.</span><span><p>2. The amines were isolated from urine using a liquid ion exchanger, then acetylated and perfluoroacylated for analysis. This procedure improved extraction efficiency and analytical sensitivity.</p></span></li><li><span>3.</span><span><p>3. The developed procedure was rapid, simple, specific and sensitive.</p></span></li><li><span>4.</span><span><p>4. Urinary levels of 5-hydroxytryptamine, 3-methoxytyramine, normetanephrine, 2-phenylethylamine, tryptamine, <span><math><mtext>m</mtext></math></span>- and <span><math><mtext>p</mtext></math></span>-tyramine in control subjects were determined using this analytical procedure and agreed with literature values.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90047-3","citationCount":"21","resultStr":"{\"title\":\"Screening for amines of psychiatric interest in urine using gas chromatography with electron-capture detection\",\"authors\":\"R.T. Coutts, G.B. Baker, D.F. LeGatt, G.J. McIntosh, G. Hopkinson, W.G. Dewhurst\",\"doi\":\"10.1016/0364-7722(81)90047-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. An electron-capture gas chromatographic procedure for the simultaneous quantitation of urinary levels of amines of psychiatric interest has been developed.</p></span></li><li><span>2.</span><span><p>2. The amines were isolated from urine using a liquid ion exchanger, then acetylated and perfluoroacylated for analysis. This procedure improved extraction efficiency and analytical sensitivity.</p></span></li><li><span>3.</span><span><p>3. The developed procedure was rapid, simple, specific and sensitive.</p></span></li><li><span>4.</span><span><p>4. Urinary levels of 5-hydroxytryptamine, 3-methoxytyramine, normetanephrine, 2-phenylethylamine, tryptamine, <span><math><mtext>m</mtext></math></span>- and <span><math><mtext>p</mtext></math></span>-tyramine in control subjects were determined using this analytical procedure and agreed with literature values.</p></span></li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(81)90047-3\",\"citationCount\":\"21\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0364772281900473\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900473","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Screening for amines of psychiatric interest in urine using gas chromatography with electron-capture detection
1.
1. An electron-capture gas chromatographic procedure for the simultaneous quantitation of urinary levels of amines of psychiatric interest has been developed.
2.
2. The amines were isolated from urine using a liquid ion exchanger, then acetylated and perfluoroacylated for analysis. This procedure improved extraction efficiency and analytical sensitivity.
3.
3. The developed procedure was rapid, simple, specific and sensitive.
4.
4. Urinary levels of 5-hydroxytryptamine, 3-methoxytyramine, normetanephrine, 2-phenylethylamine, tryptamine, - and -tyramine in control subjects were determined using this analytical procedure and agreed with literature values.
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