遗传性糖尿病对小鼠血浆、结膜、肌肉和肾皮质β - n -乙酰氨基葡萄糖酶活性的影响。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-10-01

G M Rao

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引用次数: 0

摘要

测定了20、40、70、180和360日龄正常瑞士白化病和遗传性糖尿病KK小鼠血浆、结膜、大腿肌和肾皮质中参与糖蛋白和粘多糖降解的溶酶体酶β - n -乙酰氨基葡萄糖酶的活性。与年龄匹配的瑞士白化小鼠相比，180和/或360日龄的KK小鼠组织中的酶活性显著降低。这种较低的酶活性被认为是这些组织中糖蛋白和基底膜代谢变化的反映。

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Effect of genetic diabetes on beta-N-acetylglucosaminidase activity in plasma, conjunctiva, muscle and kidney cortex of mice.

The activity of beta-N-acetylglucosaminidase, a lysosomal enzyme concerned with the degradation of glycoproteins and mucopolysaccharides, in plasma, conjunctiva, thigh muscle and kidney cortex of normal Swiss Albino and genetically diabetic KK mice of 20, 40, 70, 180 and 360 days of age was determined. The enzyme activity was significantly lower in the tissues of the KK mice of 180 and/or 360 days of age when compared with age-matched Swiss Albino mice. This lower enzyme activity was considered to be a reflection of the changes in the glycoprotein and basement membrane metabolism of these tissues.

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Biomedicine / [publiee pour l'A.A.I.C.I.G.]

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