N Oudart, K Marcher, B Lacour, R G Boulu, C Guichard
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引用次数: 0
摘要
n -乙酰- β - d -氨基葡萄糖苷酶(NAG)的尿排泄已被研究在大鼠给了潜在的肾毒性药物(乙酰水杨酸，庆大霉素)。两种药物均可诱导NAG排泄增加，这是可逆的和剂量依赖性的。提示尿NAG测定作为实验毒理学研究肾毒性作用的筛选手段具有一定的价值。
[Urinary N-acetyl-beta-glucosaminidase as index of renal toxicity (author's transl)].
Urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) has been studied in rats submitted to potentially nephrotoxic drugs (acetylsalicylic acid, gentamicin). Both drugs induced increase in NAG excretion which was reversible and dose-dependent. The date presented in this paper suggest that urinary NAG determination may have value as screening device for the study of nephrotoxic effects in experimental toxicology.
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