口服前列腺素对大鼠胃粘液分泌的影响

Janette M. Mahoney, L.David Waterbury
{"title":"口服前列腺素对大鼠胃粘液分泌的影响","authors":"Janette M. Mahoney,&nbsp;L.David Waterbury","doi":"10.1016/0161-4630(81)90054-9","DOIUrl":null,"url":null,"abstract":"<div><p>The secretion of gastric mucus may play a role in the protective effect of prostaglandins against gastric ulcers. To investigate the effect of prostaglandins E<sub>1</sub>, E<sub>2</sub>, F<sub>1α</sub>, F<sub>2α</sub>, A<sub>l</sub>, A<sub>2</sub> and 15(S)15 methyl prostaglandin E<sub>2</sub>, F<sub>1α</sub>, ester on gastric mucus secretion, these prostaglandins were given orally to rats at doses of 0.1, 1.0 and 4.0 mg/kg. The anthrone method was used to analyze the amount of mucus washed from the stomach with 2 M NaCl. Gastric secretory volume effects were also observed. All of the compounds tested increased both gastric mucus and secretory volume. The most. active compound was 15(5)15 methyl PGE<sub>2</sub> Me ester. The mucus stimulating effect of these prostaglandins, when administered locally, may be relevant to the understanding of the anti-ulcer effects of prostaglandins.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"7 2","pages":"Pages 101-107"},"PeriodicalIF":0.0000,"publicationDate":"1981-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90054-9","citationCount":"11","resultStr":"{\"title\":\"The effect of orally administered prostaglandins on gastric mucus secretion in the rat\",\"authors\":\"Janette M. Mahoney,&nbsp;L.David Waterbury\",\"doi\":\"10.1016/0161-4630(81)90054-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The secretion of gastric mucus may play a role in the protective effect of prostaglandins against gastric ulcers. To investigate the effect of prostaglandins E<sub>1</sub>, E<sub>2</sub>, F<sub>1α</sub>, F<sub>2α</sub>, A<sub>l</sub>, A<sub>2</sub> and 15(S)15 methyl prostaglandin E<sub>2</sub>, F<sub>1α</sub>, ester on gastric mucus secretion, these prostaglandins were given orally to rats at doses of 0.1, 1.0 and 4.0 mg/kg. The anthrone method was used to analyze the amount of mucus washed from the stomach with 2 M NaCl. Gastric secretory volume effects were also observed. All of the compounds tested increased both gastric mucus and secretory volume. The most. active compound was 15(5)15 methyl PGE<sub>2</sub> Me ester. The mucus stimulating effect of these prostaglandins, when administered locally, may be relevant to the understanding of the anti-ulcer effects of prostaglandins.</p></div>\",\"PeriodicalId\":76381,\"journal\":{\"name\":\"Prostaglandins and medicine\",\"volume\":\"7 2\",\"pages\":\"Pages 101-107\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0161-4630(81)90054-9\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins and medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0161463081900549\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0161463081900549","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11

摘要

胃粘液的分泌可能在前列腺素对胃溃疡的保护作用中起作用。为了研究前列腺素E1、E2、F1α、F2α、Al、A2和15(S)15甲基前列腺素E2、F1α、酯对大鼠胃液分泌的影响,分别以0.1、1.0、4.0 mg/kg剂量口服。用蒽酮法测定2 M NaCl洗胃粘液量。胃分泌量效应也被观察到。所有测试的化合物都增加了胃粘液和分泌量。最多。活性化合物为15(5)15甲基pge2me酯。这些前列腺素的粘液刺激作用,当局部给药时,可能与前列腺素抗溃疡作用的理解有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of orally administered prostaglandins on gastric mucus secretion in the rat

The secretion of gastric mucus may play a role in the protective effect of prostaglandins against gastric ulcers. To investigate the effect of prostaglandins E1, E2, F, F, Al, A2 and 15(S)15 methyl prostaglandin E2, F, ester on gastric mucus secretion, these prostaglandins were given orally to rats at doses of 0.1, 1.0 and 4.0 mg/kg. The anthrone method was used to analyze the amount of mucus washed from the stomach with 2 M NaCl. Gastric secretory volume effects were also observed. All of the compounds tested increased both gastric mucus and secretory volume. The most. active compound was 15(5)15 methyl PGE2 Me ester. The mucus stimulating effect of these prostaglandins, when administered locally, may be relevant to the understanding of the anti-ulcer effects of prostaglandins.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信