溶组织梭菌氧依赖型甲硝唑耐药性。

Zentralblatt fur Bakteriologie. 1. Abt. Originale. A: Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie Pub Date : 1981-03-01

M Füzi

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引用次数: 0

摘要

对6株溶组织梭菌的敏感性测定表明，甲硝唑的抑菌作用高度依赖于环境氧浓度。在厌氧条件下，它们是敏感的，但在增加氧浓度时，它们是中等敏感或抗性的。这种耐氧厌氧菌对甲硝唑的灵活耐药性可能会干扰敏感性测定和血液水平估计的结果，并可能影响药物对由耐氧厌氧菌引起的厌氧感染的有效性。

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Oxygen-dependent metronidazole-resistance of Clostridium histolyticum.

Sensitivity determinations with 6 strains of Clostridium histolyticum showed that the inhibitory action of metronidazole was highly dependent on the oxygen concentration of the environment. Under anaerobic conditions they were sensitive but at increased oxygen concentrations moderately sensitive or resistant. The flexible resistance of this aerotolerant anaerobe against metronidazole may interfere with results of sensitivity determinations, estimation of blood levels and it may influence the effectiveness of the drug in anaerobic infections due to aerotolerant anaerobes.

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Zentralblatt fur Bakteriologie. 1. Abt. Originale. A: Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie

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