Peter Zvolsky , Libor Jansky , Jana Vyskocilova , Paul Grof
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Effects of psychotropic drugs on hamster hibernation—pilot study
1.
1. The desynchronization of circadian and circannual rhythms may play an important role in primary affective disorders.
2.
2. Interesting biochemical as well as anatomical parallels have been found between primary affective disorders and hibernation.
3.
3. Hibernation is a periodic circannual event which is determined mainly by internal and hereditary factors, and influenced also by environmental stimuli. We employed hibernation as an animal model of periodic events and studied the effect of psychotropic drugs on hibernation in the golden hamster.
4.
4. In this paradigm imipramine clearly interfered with the hibernating process and caused significant prolongation of the prehibernation period. The results of lithium trial could not be interpreted because of methodological problems.
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