{"title":"[狗在三环抗抑郁剂和诺米芬的作用下对周围交感神经和下丘脑后部刺激的压力反应]。","authors":"V H Cicardo, G Osman Dick","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Acute experiments documented the peripheric action of tricyclic antidepressives (imipramine, chlorimipramine and amitriptyline). They evoked a significant hypotensive action (P less than 0.02), baroreceptor blockade and higher intensity and duration of pressor responses to exogenous noradrenaline, electric stimulation of the sympathetic nerves of the spleen, posterior hypothalamus or the central extremity of vagus nerve. These effects could be produced by the inhibition of noradrenaline reuptake and are antagonized by noradrenergic blockade with phentolamine. Nomifensine does not change arterial pressure, but its analeptic effect is able to awake anesthetized dogs. The pressor noradrenergic response is greater than that obtained with tricyclic antidepressives. The potentiation showed by the injection of dopamine was similar to that produced by imipramine. Injected into the cerebral ventricles of the dog, it did not changed arterial pressure, but crossed the blood-brain barrier. High doses of tricyclic antidepressives and nomifensine evoked inhibitory effects on adrenergic responses.</p>","PeriodicalId":7131,"journal":{"name":"Acta physiologica latino americana","volume":"32 4","pages":"287-93"},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Pressor response to the stimulation of peripheral sympathetic nerves and the posterior hypothalamus in the presence of tricyclic antidepressive agents and nomifensine in dogs].\",\"authors\":\"V H Cicardo, G Osman Dick\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Acute experiments documented the peripheric action of tricyclic antidepressives (imipramine, chlorimipramine and amitriptyline). They evoked a significant hypotensive action (P less than 0.02), baroreceptor blockade and higher intensity and duration of pressor responses to exogenous noradrenaline, electric stimulation of the sympathetic nerves of the spleen, posterior hypothalamus or the central extremity of vagus nerve. These effects could be produced by the inhibition of noradrenaline reuptake and are antagonized by noradrenergic blockade with phentolamine. Nomifensine does not change arterial pressure, but its analeptic effect is able to awake anesthetized dogs. The pressor noradrenergic response is greater than that obtained with tricyclic antidepressives. The potentiation showed by the injection of dopamine was similar to that produced by imipramine. Injected into the cerebral ventricles of the dog, it did not changed arterial pressure, but crossed the blood-brain barrier. High doses of tricyclic antidepressives and nomifensine evoked inhibitory effects on adrenergic responses.</p>\",\"PeriodicalId\":7131,\"journal\":{\"name\":\"Acta physiologica latino americana\",\"volume\":\"32 4\",\"pages\":\"287-93\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta physiologica latino americana\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta physiologica latino americana","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Pressor response to the stimulation of peripheral sympathetic nerves and the posterior hypothalamus in the presence of tricyclic antidepressive agents and nomifensine in dogs].
Acute experiments documented the peripheric action of tricyclic antidepressives (imipramine, chlorimipramine and amitriptyline). They evoked a significant hypotensive action (P less than 0.02), baroreceptor blockade and higher intensity and duration of pressor responses to exogenous noradrenaline, electric stimulation of the sympathetic nerves of the spleen, posterior hypothalamus or the central extremity of vagus nerve. These effects could be produced by the inhibition of noradrenaline reuptake and are antagonized by noradrenergic blockade with phentolamine. Nomifensine does not change arterial pressure, but its analeptic effect is able to awake anesthetized dogs. The pressor noradrenergic response is greater than that obtained with tricyclic antidepressives. The potentiation showed by the injection of dopamine was similar to that produced by imipramine. Injected into the cerebral ventricles of the dog, it did not changed arterial pressure, but crossed the blood-brain barrier. High doses of tricyclic antidepressives and nomifensine evoked inhibitory effects on adrenergic responses.