匈牙利新农药脲嗪的神经毒理学研究。

I Dési, J Szlobodnyik, M Karmos-Várszegi, A Strohmayer, G Bakó
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引用次数: 0

摘要

对新型总除草剂脲嗪进行了一般毒理学和神经毒理学试验。大鼠分别按急性口服LD50的1/80、1/40和1/20给药3个月。这些动物表现出体重下降和过渡性贫血。该产品有轻微的肝损伤作用。肾功能检查和尿液分析均为阴性。随着时间的推移,小鼠的学习能力呈剂量依赖性受损。在治疗结束时,无论是在休息时还是在手电筒刺激下,以及在复杂的脑电图活动中,每个频段的电活动都有所减少。神经肌电图检查未发现周围神经系统损伤。热板法显示动物的反应时间略有延长。结果表明,该化合物应仅在未开垦地区使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neurotoxicological investigation of the new Hungarian pesticide Toxurazine.

The new total herbicide Toxurazine was subjected to general toxicologic and neurotoxicologic examinations. Rats were treated with 1/80, 1/40 and 1/20 of the acute oral LD50 for three months. The animals showed a decrease in body weight and a transitional anaemia. The product had a slight liver damaging effect. Renal function tests and urine analysis were negative. With time, the learning ability of animals tested in maze for 42 days became impaired dose dependently. At the end of the treatment, both at rest and on flashlight stimulation, as well as in complex EEG activity and in each frequency band there was a decrease in electric activity. In electroneuromyographic tests no effect damaging the peripheral nervous system could be detected. The hot plate method showed the reaction time of the animals to be slightly extended. The results suggest that the compound should only be used in uncultivated areas.

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